Caleb Williams (hammy) won’t play in Week 5

Klare had been active from Week 2 through Week 4 but retreats to the inactives list with Colby Parkinson returning from a one-game absence. Puka Nacua’s absence Week 2 and Week 3 could have also played a role in Klare’s game-day status during that period, with the Rams now set to face the Bills with just three active tight ends after going through multiple games with either four or five active.

Moore’s absence leaves only Keon Coleman, Khalil Shakir, Greg Dortch, and Skyler Bell as healthy wide receivers on the active roster with Joshua Palmer also sidelined. Expect heavy snap rates for Coleman and Shakir alongside tight end Dalton Kincaid, with the possibility the team elevates their 12-personnel rates through the inclusion of Dawson Knox. Also inactive for the Bills are WR Joshua Palmer, OL Jude Bowry, OL Ar’maj Reed-Adams, DL Ed Oliver DL, Landon Jackson, and NCB Dee Alford.

Estime’s signing comes as Quinshon Judkins is dealing with an ankle injury he suffered in Week 5. Estime, who is only 23 years old, already feels like an NFL journeyman as he now heads to his fifth team in three seasons after brief stints with the Broncos, Eagles, Saints, and Vikings. The former fifth-round pick has rushed for 508 yards and three touchdowns in his career and rushed for 76-310-2 as a rookie with the Broncos. Estime could see snaps in Week 6 against the Ravens if Judkins is unable to play, but we wouldn’t expect to see anything close to a meaningful workload at this time.

Cooper, who is facing felony assault charges and domestic violence and harassment charges, appeared in court on Monday and is currently on the commissioner’s exempt list. With his pretrial set for February 19th and his new trial date set for March 2nd, it’s possible Cooper could be removed from the exempt list now that his trial is set for after the season. Cooper has not played a game for the Broncos this season.

Smith-Schuster was released by the Giants in training camp, and last worked out for the Jets in September. The 29-year-old receiver caught 33 passes for 345 yards and one touchdown last season, but wouldn’t be anything more than a depth signing if he were to sign with the Vikings or another team this season.

With the Seahawks preparing to face the Broncos on a short week, it would be a bit more concerning if JSN were listed as a DNP. The team listing him as limited on the first day of the week is encouraging after he clearly battled through an ankle injury in Week 5’s loss to the 49ers. Smith-Njigba still topped 100 receiving yards for the fourth time this season and made several big plays despite being in visible pain. We’ll continue to update his practice status throughout the week, but as long as he’s active come Thursday, JSN should be in your fantasy lineups.

It was an estimated session, but one that probably bodes pretty prescient since Hufanga left Week 5’s game with the ankle injury and was ruled out. Riley Moss (ribs) was listed as limited and would appear to have a chance to come back after being ruled out for Week 5.

No real surprise after Mendoza’s mop-up appearance in Week 5. It doesn’t appear that he’s taken a major step towards unseating Cousins — who has played well — just yet. But it remains a reasonable bet to happen in the near future.

It wouldn’t be surprising if he missed some practice time this week. Marcus Mbow would get snaps in Week 6 if Eluemunor were not able to go.

Sirianni was asked about both Barkley and DeVonta Smith, who is also dealing with a hamstring injury. Sirianni didn’t commit to either player practicing this week, but we’ll see how things look on Wednesday when the Eagles release their first injury report. Philly suddenly finds itself in desperate need of help at running back after Tank Bigsby (core) was placed on IR last week and Will Shipley (foot) was diagnosed with a partial tear in his plantar fascia that’s expected to sideline him for several weeks. If Barkley is unable to play in Week 6, Dameon Pierce and Jaydon Blue would be next in line to lead the Eagles’ banged up backfield.