49ers rule out Nick Bosa (knee/calf) vs. Seahawks

Bosa has missed two games since injuring his left calf in pre-practice warmups. He will miss his third game this weekend, but apparently the rehab progress is going well. The 49ers go on by in Week 8, and the team initially considered shutting him down until Week 9. Things are currently progressing well for the veteran pass rusher, though.

Bosa has yet to return to practice since injuring his calf two weeks ago in practice. He is listed with both knee and calf injuries and is seemingly not close to returning to in-game action. Bosa will need to practice before we can consider him ready to go for Week 5 or beyond.

This injury looked like a potential season-ender when it first occurred, so a 2-3 week absence is great news for Juszczyk and the Niners. Assuming this return timeline is accurate, Juszczyk should be able to avoid being placed on injured reserve and could return as early as Week 7, when the Niners visit the Falcons.

This would be very good news for Juszczyk, as the injury appeared far worse in real time. According to Rap, the team believes Juszczyk’s ACL is believed to be intact, but he will undergo an MRI to confirm. The veteran fullback is still likely looking at a multi-week absence, which could impact Christian McCaffrey’s effectiveness in the running game, but it sounds like he avoided the worst here.

Juszczyk suffered what looked to be a serious knee injury in the fourth quarter and didn’t return to the game after being helped off the field. He would constitute an outsized loss for Kyle Shanahan’s offense, particularly his run game designs. A long-term absence for the trusted Shanny fullback could be something of a blow for Christian McCaffrey’s weekly prospects.

The 49ers will have their stud left tackle active on Sunday. 49ers LB Dre Greenlaw (quad bruise) is questionable to play. 49ers EDGE Nick Bosa (calf) and DL Mykel Williams (knee) have both been ruled out.

Bosa strained his calf while going through his pre-practice warm-up routine on Thursday. The team has not yet identified Bosa’s expected return timeline, but the 49ers’ pass rusher will be out for some time. The 49ers also ruled out EDGE Romello Height (hand) for Week 3 against the Cardinals as well.

According to Schefter, the 49ers are deciding whether to place Bosa on injured reserve. The 28-year-old pass-rusher has yet to register a sack in his two games played this season and has tallied two sacks in five games since 2025. It’s just the latest in a string of injuries that has plagued Bosa in recent years. If he lands on injured reserve, the earliest he would be eligible to return is in Week 7 against the Falcons.

McCaffrey and Williams were listed as DNP simply for rest, while Bosa had a rest/knee designation and Greenlaw had a rest/Achilles designation. This is notable as the 49ers have several key veterans who have dealt with injuries throughout their career and practice reps will be managed for these players, especially coming off a Week 1 in Australia. McCaffrey reportedly dealt with cramps in the 49ers’ Week 1 win over the Rams; though he is not injured, his experiences with Achilles tendinitis will certainly lend to rest days throughout the season. We expect the 49ers to continue to rest veterans in practice throughout the season in an effort to remain healthy.

Kittle gets in another limited practice ahead of the 49ers’ Week 1 Australia game against the Rams. We expect him to continue to get limited practices in beyond this week as the 32-year-old nurses his Achilles. Also limited was FB Kyle Juszczyk (finger). Both are still in line to play this week.