McCaffrey entered Week 1 just three days removed from an in-practice calf tweak. His five first-quarter touches were reasonable, though admittedly a team-high. 49ers head coach Kyle Shanahan threw caution to the wind as the game progressed, loading up McCaffrey with 8-9 touches in each of the next three quarters. Both George Kittle (hamstring) and Jauan Jennings (shoulder) were forced from play, helping McCaffrey earn a team-high seven targets in the second half. The veteran running back looked good as a receiver, but was unable to get things going on the ground. He gets a far softer defensive front next week, against the Saints, keeping him firmly locked into the elite RB1 tier.