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    Trent Williams (neck) will not practice on Wed.

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    49ers LT Trent Williams (neck) did not practice on Wednesday.

    Williams still has a chance to play in Week 4 against the Broncos, and he does not necessarily need to practice. The 49ers could choose to play it conservatively by sitting him until he is fully ready to go, though. We will see how the week unfolds.
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  • SF Tackle #71
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    The 49ers will have their stud left tackle active on Sunday. 49ers LB Dre Greenlaw (quad bruise) is questionable to play. 49ers EDGE Nick Bosa (calf) and DL Mykel Williams (knee) have both been ruled out.
  • SF Tackle #71
    49ers coach Kyle Shanahan said earlier this week that Williams was expected to resume practicing today. The fact that he is on track is a good sign for his Week 4 availability. 49ers LB Dre Greenlaw (bruised quad) is still sidelined.
  • SF Tackle #71
    The 49ers don’t play until Sunday, so we’re assuming Shanahan is referencing when we should first expect Williams to take the practice field this week. Williams suffered what was classified as a stinger in Week 3’s win over the Cardinals, but appears to have avoided any serious injury. Shanahan said the team plans to manage he and LB Dre Greenlaw (quad) throughout the week, and didn’t rule out either player playing in Week 4 against the Broncos.
  • SF Wide Receiver #5
    According to ESPN’s Nick Wagoner, “it was unclear exactly what happened to Evans.” He got hit hard in the sternum on a catch over the middle, but remained in the game for a few plays before needing help from the training staff to get off the field. Shanahan said the team couldn’t tell if Evans broke a rib or injured his oblique, but he believes those questions will be answered tomorrow, indicating Evans will likely undergo imaging. He entered the game with a hip injury. Wagoner adds that LT Trent Williams (stinger) and LB Dre Greenlaw’s (quad) injuries “seemed less severe” than Evans’ injury.
  • SF Tackle #71
    Williams left in the third quarter, taking the cart to the 49ers locker room. The veteran left tackle was officially diagnosed with a stinger and is questionable to return. Vederian Lowe is in at left tackle with Williams out.
  • SF Running Back #23
    McCaffrey and Williams were listed as DNP simply for rest, while Bosa had a rest/knee designation and Greenlaw had a rest/Achilles designation. This is notable as the 49ers have several key veterans who have dealt with injuries throughout their career and practice reps will be managed for these players, especially coming off a Week 1 in Australia. McCaffrey reportedly dealt with cramps in the 49ers’ Week 1 win over the Rams; though he is not injured, his experiences with Achilles tendinitis will certainly lend to rest days throughout the season. We expect the 49ers to continue to rest veterans in practice throughout the season in an effort to remain healthy.
  • SF OFFENSIVE TACKLE (SUB) #71
    Fresh off a two-year contract extension signed in April, Williams enters his 17th season in the league and said 2027 will “probably be his last.” The 12-time Pro Bowl tackle has been a mainstay for the 49ers up front since being acquired prior to the 2020 season, receiving All pro honors in 2021, 2022, and 2023. “I’m toying between the idea of going until I can’t no more and just leaving while I still got some good product left and I get ran out of the league, " Williams said Wednesday. “It’s hard not to compete when you can, so we’ll see.”
  • SF OFFENSIVE TACKLE (SUB) #71
    Williams and the Niners appeared to be at an impasse earlier this offseason after the team opted not to pick up his $10 million option bonus and reporters noted that the 38-year-old was said to be available in trade. Williams had one year left on his old deal, but with his new contract extension, he will be under contract through 2027. Of the $50 million Williams is set to receive, $34 million will be guaranteed. He allowed just four sacks on 32 pressures last season, per PFF, earning a 79.9 PFF pass-blocking grade.
  • SF OFFENSIVE TACKLE (SUB) #71
    Lynch made clear he wanted to avoid saying a new deal is “right there” because things can change quickly, but he believes the two sides “are on the precipice of something good happening.” Lynch complimented Williams’ consistent play quality, saying the 37-year-old blocker is one of the great players to ever play the game while acknowledging that Williams’ age is a big factor from the team’s perspective. The 49ers chose not to exercise Williams’ $10 million option bonus earlier this month, which would have allowed them to move money around via future void years. The decision was a positive indicator that they believe a new deal can be agreed upon. Things are seemingly still headed in the right direction. Williams is scheduled to enter free agency in 2027.
  • SF OFFENSIVE TACKLE (SUB) #71
    Williams is scheduled to enter free agency in 2027, and up until now, none of his 2026 salary was guaranteed. Today’s option deadline guarantees Williams $10 million and brings his salary cap number to nearly $47 million. Had the 49ers exercised the option, it would have allowed them to spread the $10 million out over future years. The 49ers still want to reduce his cap hit and Williams reportedly wants more guaranteed money. It is unclear if the 37-year-old left tackle also wants an extension beyond this season. Despite the increased cap hit, Schefter reports that the 49ers are “not overly concerned” about today’s increased cap hit and are planning to rework his contract before the 2026 NFL Draft.

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    Marcus Mariota (knee) is questionable to return in Week 4 against the Colts.

    Colts EDGE Laiatu Latu landed on Mariota’s right ankle while taking him down for a sack in the first quarter. Mariota was slow to get up and immediately made his way to the blue tent. He walked to the locker room after a brief stay in the tent. Seventh-round rookie Athan Kaliakmanis is under center for the Commanders.
  • PHI Wide Receiver #6
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    NFL Network’s Mike Garfaolo reports DeVonta Smith (hamstring) is “at very best” questionable for Week 5 against the Jaguars.

    Smith has already been ruled out for Week 4. The Eagles take on the Jags in London next week. It sounds like fantasy managers should be prepared to be without their start receiver for that contest as well. Dontayvion Wicks currently profiles as the team’s top wideout, but it’s hard to imagine the team not getting first-round rookie Makai Lemon more involved as well. Both players are solid FLEX options for Week 4.
  • HOU Defensive End #90
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    NFL Network’s Ian Rapoport reports Jadeveon Clowney (knee) is expected to play in Week 4 against the Cowboys.

    Clowney hasn’t played since injuring his knee in Week 1. Though he isn’t expected to be a major factor in the Texans’ plans, Houston’s defense hasn’t been the shutdown unit that it was last year. They currently rank as a below-average team in EPA per play allowed. Clowney won’t change their fortunes overnight, but he will hopefully help them make incremental improvements.
  • TEN Running Back #2
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    NFL Network’s Ian Rapoport reports Tyjae Spears (ankle) is expected to play in Week 4 against the Ravens.

    Spears played through the ankle issue last week and there was no indication during this week’s practice that he suffered any sort of setback. He is good to go for Week 4, though fantasy managers can’t count on him for much. He touched the ball just three times last week.
  • CHI Offensive Lineman #70
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    Bears placed Braxton Jones (knee) on injured reserve.

    Jones injured his knee and was considered “week to week” going forward. The good news is that this means it won’t be season-ending IR, but the Bears will be without their starting left tackle for at least four games. Theo Benedet will start in his place this week. Now healthy, Ozzy Trapilo could take over that job in the coming weeks as well.
  • CAR OFFENSIVE TACKLE (SUB) #57
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    NFL Network’s Ian Rapoport reports Monroe Freeling (concussion) will play in Week 4 against the Lions.

    The Panthers entered the season down both of their starting tackles. They will also be without left guard Damien Lewis this week. Getting Freeling back is a big win for Bryce Young and the offense. Freeling has struggled in pass protection so far but is serviceable in the run game.
  • SF Linebacker #57
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    ESPN’s Jeremy Fowler reports Dre Greenlaw (quad) is expected to play in Week 4 against the Broncos.

    The 49ers are already banged up on defense with Nick Bosa and Mykel Williams ruled out on Friday. Greenlaw was listed as questionable after getting in a single limited practice. He has 22 combined tackles, 11 defensive stops, and one pressure this year.
  • PIT Defensive Tackle
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    NFL Network’s Ian Rapoport reports Derrick Harmon (foot) “is expected to miss a few weeks.”

    Rapoport noted that IR is an option, but the injury is not considered long-term. Harmon suffered the foot injury on Thursday against the Browns. He was carted to the locker room and was later spotted wearing a boot on the sidelines. The second-year tackle had 1.5 sacks in three games before leaving Week 4 early. His potential breakout campaign will now be put on hold for upwards of a month.
  • DET Tight End #87
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    NFL Network’s Ian Rapoport reports Sam LaPorta and the Lions “have broken off contract talks.”

    Rapoport did note that the Lions could make another push to sign LaPorta later this year, so the door isn’t entirely closed. LaPorta is set to become a free agent next offseason. The team could, however, place the franchise tag on him. He has gotten off to a quiet start with 14 catches for 144 yards and one score. LaPorta is currently on pace for a career-low in yards per game. He would still have plenty of suitors in free agency, even if the counting stats don’t improve this year.
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    ESPN’s Adam Schefter reports Baker Mayfield (thumb) is expected to miss “anywhere from three to six weeks.”

    Previous reports put the timeline at 2-4 weeks, so it’s possible the injury is worse than initially expected. The good news is that testing revealed no ligament or tendon damage in Mayfield’s thumb. Per Schefter, Mayfield’s return will depend on how quickly he can grip the ball. That is typically the first step in throwing a football. For now, UDFA rookie Jalon Daniels will draw the start. He is worth a look in Superflex leagues but can’t be played in one-quarterback formats.