Jefferson (ankle) plans to play, but status TBD

After three straight big weeks, Kittle finally came back down to earth in Sunday’s win over the Seahawks. His longest reception came on a 13-yard gain in the third quarter, but proved inconsequential after Deebo Samuel lost a fumble on the following play to end the drive. Kittle has been targeted 19 times over the last three weeks and has gone for 70-plus yards in three of his last four games. He should be primed for a bounce-back next week when the Niners play host to the Commanders on Monday night.

LaPorta got involved on the Lions’ third drive, making a clutch 12-yard grab on 4th-and-3 while suffering what the officials deemed an unnecessarily rough hit by LB Mack Wilson at the end of the play. He chipped in two catch-and-run plays on the following drive. The first being an 11-yard play that was controversially ruled down in front of the sticks. Coach Dan Campbell called his number on the next play, resulting in an effortless 38-yard touchdown down the right side of the field. LaPorta tacked on an eight-yard catch and a 19-yard catch in the second half as the Lions cruised to a blowout win. He goes on bye next week but returns to the TE1 ranks in Week 7 against the Packers.

Barner continues to be a non-factor in the Seahawks’ passing game. Outside of a Week 3 game against the Commanders in which he went for 5-69-0 on nine targets, Barner has totaled 53 yards in his other four games combined and has yet to find the end zone this season. Barner won’t be on the streaming radar in Week 6, even with four teams on bye.

Jared Goff gave TeSlaa two chances to contribute today. The first was a 3rd-and-13 pass on the Lions’ second drive, just beyond the sticks, in which TeSlaa went aerial and fully horizontal, trying to make the diving catch. The pass, unfortunately, fell incomplete. Goff went back to him on the fifth drive, firing a pass — just a touch too high — to the second-year wide receiver who was wide open on a crossing route, racing across the back of the end zone. TeSlaa leapt for it and got a hand on it, but he couldn’t come down with it. TeSlaa takes his goose egg into the Lions’ Week 6 bye. With any luck, it hatches into a FLEX-relevant stat line against the Packers in Week 7, though he remains a boom-bust pass catcher.

Holani put the ball on the turf twice in this one, but it was his fumble with 13 seconds left in the first half that proved to be one of the more costly mistakes of the game. With the Seahawks simply looking to get to halftime, Holani took a handoff from Sam Darnold for what should have been the final play of regulation. Instead, the third-year back had the ball knocked out and into his own end zone, which resulted in a Niners touchdown after it was recovered by DT Gracen Halton for the score. Holani hasn’t emerged as the late-round value fantasy managers hoped for this offseason and is fully off the fantasy radar for Week 6 against the Broncos.

The Lions’ speedster only caught two passes today, but he made them count. Williams’ first catch was a nine-yard, fourth-down touchdown on the Lions’ fifth drive. He nearly hauled in a 25-yarder via a play-action target on the sixth drive, but Cardinals CB Max Melton batted it away. He was open for an explosive gain on the next drive, but Jared Goff checked down to Sam LaPorta about 10 yards beneath Williams. A few plays later, Williams dusted his coverage defender for a 39-yard score from bunch formation, hauling in the touchdown pass in stride in the end zone. Goff later gave him another touchdown chance on a downfield throw targeted inside the Cardinals’ five-yard line, but Williams couldn’t secure it. He’ll now take a week off with the Lions’ Week 6 bye, but return as a WR2 against the Packers in Week 7.

Campbell will undergo an MRI tomorrow to fully assess the injury, but it seems likely that Drake Maye will be playing without his left tackle for a few weeks. They face the Jets, Bears and Dolphins over the next three weeks. Keeping Jets rookie EDGE David Bailey at bay could prove challenging.

Wilson again led the Seahawks in rushing sans Jadarian Price. He handled all but four of the team’s running back carries in this one and found the end zone on a two-yard plunge in the first quarter to tie the game at 7-7. Wilson coughed up a key fumble in the second quarter that gave the Niners the ball on Seattle’s 11-yard line. On the following play, the Seahawks would allow an 11-yard touchdown run to Christian McCaffrey to put the Niners back out in front. Assuming Zach Charbonnet (Achilles) is at least one more game away from returning, Wilson will be on the RB2 radar in Week 6 when the Seahawks take on the Broncos on Thursday night.

McCaffrey’s lone touchdown came on an 11-yard touchdown run immediately after the 49ers had recovered a fumble by Emanuel Wilson. He hasn’t had the gaudy yardage totals we’re accustomed to seeing, but fantasy managers won’t be mad at this performance. While McCaffrey has yet to rush for 100 yards in a game this season, he’s gone for 80-plus yards from scrimmage in three of five games and has scored in four straight. He continues to be the only fantasy-relevant running back on the Niners and is set up to smash in Week 6 against the Commanders on Monday Night Football.

The Seahawks face the Broncos in Week 6’s Thursday Night Football game. Late last week, Macdonald acknowledged that the short turnaround time would make it difficult to ramp up Charbonnet as planned. The Seahawks are set to scale back the intensity at practice this week, which runs counter to the rehab plan. The Seahawks face the Chiefs in Week 7’s Sunday Night Football game. That seems like a plausible return date at this point.