Tyler Smith (thumb) listed as questionable

Holani was listed as a limited practice participant due to a rib injury on Wednesday. The 26-year-old operated as a passing-down backup to Emanuel Wilson in Week 4 with Jadarian Price out. Unless he misses practice later this week, he is still on track to play in Week 5, though Holani does not have a large enough role to achieve fantasy relevance.

Neither Surtain or Riley Moss (ribs) practiced on Wednesday. Head coach Sean Payton said the Broncos don’t anticipate placing Surtain on injured reserve. The injuries to both corners look to be shorter-term; Surtain is week-to-week while Moss’ return timeline is not disclosed yet. Both are on the wrong side of questionable for Week 5 against the Chargers.

Penning suffered a concussion in the Chargers’ Week 4 loss and is still in the protocol to start the week. Also not practicing was G Kayode Awosika, who has missed multiple games with a fibula injury. Both are in jeopardy of missing Week 5, dealing serious blow to Justin Herbert’s offensive line.

In addition to Johnston, TE Charlie Kolar (forearm) and WR Brenen Thompson (quad) were also limited. Johnston has played in every game this season, but pops up on the practice report with a chest issue on Wednesday. He is not yet in danger of missing Week 5, barring setbacks later in the week. Neither Thompson nor Kolar have played since Week 2 but both have a chance to return this week against the Broncos. With Ladd McConkey (foot) not practicing, Johnston may have fantasy value as the Chargers’ No. 1 wideout this week.

Though head coach Jim Harbaugh ambiguously said we would get McConkey in practice, the 24-year-old is officially listed as a non-participant on Wednesday. Harbaugh also previously stated McConkey will be day-to-day after he re-aggravated the foot injury in Week 4. Ultimately, it’s unclear if McConkey will play this week given he generally pushes through injuries with little practice time, but a re-aggravation could lead to a game missed this time around. Stay tuned for practice reports later in the week to provide clarity on his Week 5 status.

An already disappointing season continues to tumbler for the Chargers. LT Rashawn Slater (ankle) is already out this week and Alt will join him on the injury report. Neither starting tackle has been able to stay healthy over the course of their careers, making life difficult for QB Justin Herbert. Though Alt is expected to miss this week against the Broncos, Rapoport adds that there are “no plans” for him to go on injured reserve.

Charbonnet is starting to ramp up to a return from his torn ACL last season. The Seahawks opened up his practice window and he was limited on Wednesday. He is already ruled out for Week 5, but a Week 6 return is not out of the picture just yet.

Bosa has yet to return to practice since injuring his calf two weeks ago in practice. He is listed with both knee and calf injuries and is seemingly not close to returning to in-game action. Bosa will need to practice before we can consider him ready to go for Week 5 or beyond.

Anderson popped up on the injury report with an ankle issue to open the week. As one of the league’s elite pass-rushers, the 25-year-old is a key cog to the Texans defense. He did not practice Wednesday, putting his Week 5 status in jeopardy. Anderson still has chances to practice later this week and play against the Titans, but any time missed puts the 0-4 Texans in an even deeper hole.

Smith still has not returned to practice since last week, continuing to deal with a hamstring injury. Given his lack of practice reps ahead of travelling to London for Week 5, Smith is on the wrong side of questionable for this week’s matchup against the Jaguars. Also not practicing was WR Hollywood Brown (ankle). The Eagles will play Week 5 with a severely banged-up skill position group.