Tottenham Hotspur center back Toby Alderweireld has left Wednesday’s UEFA Champions League visit from Real Madrid within 25 minutes of kickoff at Wembley Stadium.
Alderweireld was running alongside Casemiro in the Real 18-yard box, and looked to have injured his hamstring.
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Moussa Sissoko entered the fray, with Eric Dier dropping into the back three with Jan Vertonghen and Davinson Sanchez.
Spurs also count Juan Foyth amongst center back options with Crystal Palace visiting Wembley Stadium at 7 a.m. ET Sunday.
Dele Alli scored soon after the substitution to give Spurs a 1-0 lead.
