Nico Collins (hamstring) limited in Wednesday practice

Knox cashed in on a touchdown grab from one yard out in the second quarter for his first score of the season. While his snaps should remain high in an offense that rotates pass-catchers at an elevated rate, his primary contribution remains his blocking prowess. He remains a player unlikely to contribute meaningful counting stats on a weekly basis and is best left on the waiver wire.

Shakir continued in a gadgety role for the Bills, primarily working the short areas of the field in addition to receiving snaps out of the backfield. That could change in the immediate future after lead receiver DJ Moore departed in the second quarter with what appeared to be a significant shoulder injury. Even so, Shakir is best left on the waiver wire in all but the deepest fantasy leagues.

Coleman could be a hot name on the waiver wire following Week 2 after DJ Moore departed with what appeared to be a significant shoulder injury in the first half. The third-year veteran continues to tease at untapped upside in this high-powered offense but has yet to fully break through for consistent production. Maybe that changes now as his role potentially grows without Moore. It will also be interesting to see how, if at all, his route tree changes in the absence of Moore, particularly considering the team has Joshua Palmer to operate as the field-stretching, Z-type receiver, the latter of whom caught his only target for a 43-yard touchdown on a broken coverage against the Lions. Coleman is a speculative waiver addition ahead of a much more forgiving matchup against the Jets in Week 3.

Kincaid truly did it all in this one, routinely in the middle of the blocking scrum on long James Cook runs in addition to his work through the air. His 95 yards handily paced the team, with his first touchdown of the young season coming from 16 yards out near the end of the second quarter. Kincaid remains one of the most efficient pass-catchers in the league on a per-route basis and has worked his way into the upper echelon of fantasy assets at the position. He remains a locked-in TE1 when the Bills host the Jets in Week 3.

Cook jumped out to a scorching start on the ground, reaching the century mark in rushing before the half. Still, fantasy managers were left scratching their head as they watched Josh Allen account for three touchdowns from inside the five, two on the ground and one through the air. It wasn’t until a 22-yard carry that was down at the one late in the fourth quarter that the team rewarded Cook with a short-yardage touchdown, finally allowing fantasy managers their first taste of sweet touchdown copium from their first-round draft pick on the young season. Cook is likely to remain busy when the Bills host the Jets in Week 3, where he will remain a locked-in RB1.

Was it ever a doubt that Super Josh would make an appearance in the franchise’s first game in their new stadium? To the utter dismay of James Cook fantasy managers, Allen accounted for three touchdowns from inside the five against the Lions, two with his legs and one with his arm, extending his NFL-record for games with multiple rushing touchdowns and multiple passing touchdowns to 10 in the process. The unquestioned overall QB1 in fantasy circles continues to prove the doubters wrong as the Bills surge to 2-0 atop the AFC ahead of a home meeting with the Chargers in Week 3. Allen remains a top-tier fantasy asset until pigs fly.

Williams continues to be primarily utilized as a deep threat in the Detroit offense, which is not the development fantasy managers were expecting following offseason reports that his route tree would be expanded in the new year. The mounting injuries along the offensive line have limited Goff’s time in the pocket to the point where Williams rarely has enough time for his routes to develop, leading to the down production through two weeks. Whether either of those two variables changes in the immediate future remains to be seen, leaving us to treat Williams as nothing more than an upside WR3 in the interim. He will be a difficult start in Week 3 when the Lions host the Jets.

LaPorta combined with Amon-Ra St. Brown and Jahmyr Gibbs to be the primary targets for quarterback Jared Goff on a night where relentless pressure from the Bills forced the offense to primarily attack the intermediate areas of the field. That could be the norm for this offense moving forward considering the mounting injuries along their offensive line, which are likely to be felt the most against opponents with a legitimate pass rush. That may not be the case in Week 3 when the Lions host the Jets, a team that is likely to also utilize elevated rates of zone coverage. LaPorta has had stark man-zone splits throughout his career and could see less volume due to matchup. He’ll be a low-end TE1 against the Jets.

St. Brown did not catch his first pass until six minutes left in the second quarter but was the primary cog of the offense after the break as the Lions worked to overcome multiple 17-point deficits. He found paint for the first time on the team’s first possession after the break before adding a second in the two-minute drill from 27 yards out. St. Brown now has 209 yards and four touchdowns on 19 receptions through two games an looks every bit of the elite WR1 fantasy managers invested a first-round pick into this offseason. Although volume through the air might be more difficult to come by in Week 3, St. Brown remains a top-tier WR1 when the Lions host the Jets in Detroit.

Gibbs was effectively the entire game plan out of the gates, scoring the team’s only first-half touchdown from 11 yards out in the second quarter. He would be used far less after the break as the Lions attempted to come back from multiple 17-point deficits, although the six receptions on eight targets and a touchdown through the air helped push his counting stats into clear RB1 territory for the second consecutive week to start the season. Fantasy managers that were lucky enough to secure the 1.01 in drafts this offseason are sure to be content with the early returns. Gibbs will once again be an elite fantasy option when the Lions host the Jets in Week 3.