Saints RB Devin Neal picks up hamstring injury

Collins tore his patellar tendon during the 49ers’ first Australia practice last night. It’s an unfortunate break for the 2025 second-round pick, set to start Week 1 for the 49ers defensive line against the Rams. Collins’ biggest play last season was forcing a goal-line Kyren Williams fumble in Week 5. He will instead need knee surgery and begin a journey back from injury for 2027. The 49ers will reach into their defensive tackle depth and may activate Kevin Givens or Sebastian Valdez from the practice squad for Week 1 in Australia against the Rams.

According to Garafolo, the Steelers made an offer to Porter but it is “not good enough” for a contract extension to be imminent. This seems to be the first offer Pittsburgh has made to the 26-year-old, so there are at least negotiations happening. With both Devon Witherspoon and Christian Gonzalez getting top-of-market deals done, all eyes are on Porter as last among the big cornerback extensions to get done. Garafolo adds the Steelers will not negotiate into the season past Week 1, so both sides have a few days to get a deal done before talks are tabled until the end of the season.

Garrett was a non-participant in practice Tuesday, but it looks to be a load management day with other Rams players listed as DNP due to rest and head coach Sean McVay saying Tuesday he expects Garrett to play Week 1. Though the team will be without Aaron Donald for opening day, the Rams are still expecting to have Garrett good to go against the 49ers.

Kittle continues to work his way back from an Achilles tear in January and is seemingly on track to play Week 1. He practiced on Monday and gets in a limited practice again on Tuesday. Offensive coordinator Klay Kubiak was confident in Kittle’s availability this week, saying the 32-year-old looked good while the team practices in Australia. The entire 49ers offense practiced in some capacity Tuesday. Kittle’s chances of playing are trending upward; he’s a low-end TE1 if he plays against the Rams this week.

The Buccaneers apparently reached out to Mayfield’s agent over the weekend; deadline do drive action after all. Mayfield is now under contract through his age-34 season. It’s not exactly a curious move for the Buccaneers — they didn’t have much of an avenue to find another quarterback given where they usually pick and rookie UDFA Jalon Daniels is their current backup. It is still a little surprising they let it twist in the wind as long as it did. Mayfield likely will be near the $50 million average annual value club once all the figures come in. (Some of this will be folded into the already-existing one-year contract.) He’ll be a reasonable superflex QB2 with a shot to rebound now that last year’s injuries are behind him.

He practiced in full on both Monday and Tuesday and seems set to go for the Wednesday opener. We’ll keep an eye on Barmore’s practice status going forward but the 27-year-old is definitely a candidate to get vet days this season.

Henderson did not practice at any point this week and should be considered questionable heading into Week 2’s games. Rhamondre Stevenson will get the bulk of the load against Seattle and should factor into the RB2 equation despite a tough matchup on paper. The Patriots also ruled out Ben Brown (knee), who did not travel with the team to Seattle.

Even if Horton does play, he’s unlikely to be more than the fourth receiver behind Rashid Shaheed, Cooper Kupp and all-world Jaxon Smith-Njigba. The second-year receiver looked great early in 2025 but has dealt with a ton of injuries ever since, leading the Seahawks to their midseason trade for Shaheed last year.

One of Seattle’s other projected starters on defense, Ty Okada, was ruled out with a hamstring injury. It would certainly be a boon to Rhamondre Stevenson’s value if Emmanwori can’t go on Wednesday. Emmanwori had surgery on his ankle in July and opened camp on the PUP list. He’s generally been regarded as more doubtful-than-questionable, but there’s a chance he’s able to go based on this listing.

Heavily load-managed in the offseason, Garrett will enter his age-31 season fresh and ready to try to top last year’s 23-sack season in a new defense. We won’t be surprised if Garrett continues to be listed on the injury report going forward, but if he’s going to play through this there’s probably no need to be concerned about the report unless new concerns arise.