Los Angeles

Chargers

CB Asante Samuel Jr. (shoulder) was also ruled out. While an elite secondary is not required to limit Bo Nix, the Chargers’ defensive losses are notable here. Nix could have an easier-than-expected time returning QB2 value.

Bosa was limited on Friday after sitting out practice on both Thursday and Friday. The talented edge player seems likely to miss another week, nursing his persistent hip issue.

Edwards’ absence ignites a battle between enticing rookie Kimani Vidal and the hulking Hassan Haskins for the No. 2 role. Fantasy managers should consider stashing either player, though Vidal’s three-down profile offers more upside.

Alt closed the week with two Full Participant practice designations, so he is good to go. RT Rashawn Slater (pectoral) was limited all week and appears to be truly questionable.

Herbert faces the Broncos’ blitz-heavy defense in Week 6. His low passing volume coupled with the difficult matchup keep him firmly in the QB2 ranks. The Chargers should also get at least one starting tackle back in the lineup this week.

This is the same ankle Herbert played through in Week 4. With the Chargers coming off a Week 5 bye, Herbert has had plenty of time to rest his ankle and should be good to go, barring any setbacks. He’ll need to be at the top of his game against a Broncos defense that has been among the league’s best this season. Herbert shouldn’t be viewed as anything more than a QB2 in fantasy this week.

Two straight DNPs to open the week for Edwards puts him on track to miss Week 6’s game against the Broncos. He’ll have one more day to try and get on the field, but if he’s unable to go, we could see rookie Kimani Vidal activated for the first time this season.

Bosa, who has struggled to stay healthy in recent seasons, has already missed two games because of the hip issue. The fact that he is not practicing coming out of LA’s bye week suggests he is still a long way out from returning. Cornerback Ja’Sir Taylor (fibula), who also missed Week 4, did not practice either. Expect the Chargers to remain undermanned on defense for Week 6 versus Denver.

Edwards was already falling out of favor before LA’s Week 5 bye. He had nine carries for 28 yards over the previous two weeks. An ankle issue after a week off isn’t going to do him any favors either. If he is forced to miss Week 6, rookie Kimani Vidal could be active for the first time this year.

Herbert played through a high-ankle sprain in Week 4 with disastrous results. He struggled to move around the pocket and threw for 179 yards plus one touchdown en route to a 10-point performance from the entire offense. LA lost to the Chiefs by seven points. The Chargers’ Week 5 bye should help Herbert get back on his feet for their upcoming matchup with Denver. LA’s run-heavy approach will keep him in the QB2 ranks.