49ers declared RB Isaac Guerendo, WR Ricky Pearsall, DL Robert Beal Jr, DL Kevin Givens, LB Curtis Robinson, CB Renardo Green, and CB Chase Lucas inactive for Week 16 against the Colts.
Pearsall’s absence should thrust Kendrick Bourne into a primary perimeter role opposite Jauan Jennings, the latter of whom is likeliest to see his volume boosted slightly. Furthering that potential is the absence of Indianapolis cornerback Sauce Gardner, likely shifting the Colts’ defense back into heavy rates of Cover-3 after utilizing man coverages at one of the highest rates in the league with Gardner on the field this season.