If you’re not familiar with the reserve/left squad list, that’s okay, it is something typically reserved for players about to retire. The awkward saga between Aiyuk and the 49ers appears to be ending in a messy divorce, with the recent move by the team all but ensuring the two sides split in the coming offseason. The transaction also officially ends Aiyuk’s 2025 season before it began. Stay tuned through the offseason.

The veteran quarterback was in the midst of a career year before it was halted due to a torn Achilles. The six-to-eight month recovery window gives him the potential to be ready for preseason camp ahead of the 2026 regular season, which is sure to figure into the team’s plans moving forward. That will likely be a point of continuous discussion surrounding the Colts considering Jones was playing the 2025 season on a one-year, “prove-it” deal.

McCaffrey dealt with an illness that limited his practice participation this week. He was removed from the injury report Friday before being added back and listed as questionable Saturday with a bak injury. It is unclear when the new ailment surfaced. Late-week additions to the injury report are never something fantasy managers want to see, also leading to a significant decision in the first week of fantasy playoffs considering the 49ers don’t play until the afternoon Sunday. McCaffrey will remain a top tier RB1 if active against the Titans. Fantasy managers might want to hedge by grabbing Brian Robinson off of waivers, if available. ESPN’s Adam Schefter later followed up the report by saying McCaffrey will go “good to go” Sunday.

Schefter reports that the Colts are signing Rivers to the active roster. The quarterback who turned 44 earlier this week and ranks seventh in all-time passing yards entering Week 15 was a semifinalist for this year’s Pro Football Hall of Fame class. Rivers will now have to wait another five years before he’s eligible again, assuming he retires again after this season. Fantasy managers considering using the signal caller who was in the same draft class as Eli Manning, who last played in 2019, in the fantasy playoffs have lost the plot.

Odunze is listed as questionable with a foot injury after missing last week’s Bears loss in Green Bay. The 23-year-old wide receiver practiced all week in a limited fashion. Odunze had just two catches and eight yards in his last game action against the Eagles in Week 13. If active, he’ll be a risky FLEX option for desperate teams in the first round of the fantasy playoffs.

Add backup RB Emanuel Wilson wherever available. Jacobs is seemingly on track to play on Sunday, but it cannot hurt to be safe. Wilson operated as the team’s featured running back with Jacobs sidelined against the Vikings a few weeks ago, rushing 28 times for 107 yards and two touchdowns. The Broncos’ elite defense will put up a fight, but Wilson would be a volume-based RB2 if Jacobs cannot play.

Pickett may only be getting a one week audition here, as Carroll said that Geno Smith “will be back” against the Texans in Week 16. Against the Eagles’ stellar pass defense, Pickett is best approached as a QB3 in superflex leagues and even an optimistic view can’t see him as better than a low-end QB2 with almost nothing around him beyond Brock Bowers and Ashton Jeanty. It’s just not an ideal situation, even if he did look decent in relief of Smith in Week 14.

Riley Leonard (knee) has practiced in full all week, so it sure seems like he’d be available to go if the Colts wanted him to. Of course, if they really wanted him to go, they probably would not have signed a 44-year-old grandfather in the first place. So there’s that. We’ll likely get a report that Rivers will start at some point in the next 36 hours. He’s not to be trusted in superflex leagues in his first start in five years.

Higgins has been concussed twice over the last three weeks and will now miss a second game due to his brain injury. Despite being limited in both Wednesday’s and Thursday’s practice, the star receiver felt like a long shot to play after landing in protocol following Week 14’s game against the Bills. When Higgins missed Week 13’s game against the Ravens, backup Mitchell Tinsley stepped up to run a season-high 31 routes while also drawing a season-high eight targets. He could have some upside as a dart-throw WR4 in deeper leagues.

With extra time to heal up after getting concussed in a Thursday night matchup against the Lions, Lamb is now good to go in a pivotal Week 15 game against the Vikings. Lamb turned in arguably his best performance of the season before going down last week, totaling six catches for a season-high 121 yards in just one half of play. He can be trusted as a WR1 in this week’s fantasy playoff matchups.