“I think he’s going to be fine,” Murphy told reporters after Misiorowski left Friday’s start during the sixth inning of a no-hit bid with a right hamstring cramp. It’s worth noting that the hard-throwing 24-year-old will still need to make it through a bullpen session before he’s officially cleared to take the ball against the Cardinals on Wednesday. However, it certainly sounds like his early exit was merely out of an abundance of caution.

No pressure. Gibson, the Orioles’ top pitching prospect, will make his major-league debut at Yankee Stadium, with Shane Baz likely pushed back to Monday. The 23-year-old right-hander is one of the more intriguing arms in the minors, but this is an extremely difficult spot for fantasy managers to trust him. He offers legitimate strikeout upside after posting a stellar 166/44 K/BB ratio across 120 1/3 innings at three levels in Baltimore’s system last season, giving him a path to immediate fantasy relevance. He’s talented enough to warrant a speculative roster spot in most formats, even if expectations should be tempered in this challenging matchup.

Matt Shaw takes over at second base with Hoerner on the bench for some additional rest after making an early departure from Friday’s series opener at Wrigley Field with neck tightness. The 28-year-old second baseman has been a revelation, hitting .297/.374/.461 with four homers, 26 RBI and seven steals through 32 games, as an increase in over-the-fence power has pushed him into true superstar territory this season. There should be a clearer picture regarding his status at some point this weekend, but fantasy managers should consider him day-to-day for now.

Domínguez is back at DH and hitting sixth after sitting out Friday’s series opener to undergo additional imaging on his left elbow, which didn’t reveal any fractures. The 23-year-old former top prospect suffered a contusion when he was hit by a pitch during Wednesday’s series finale against the Rangers. He’ll have an opportunity to show something against right-handed starters for at least a couple games while Giancarlo Stanton (calf) remains on the injured list.

Kurtz drew a seventh-inning walk on Friday night at Sutter Health Park, tying Barry Bonds, who accomplished the feat back in 2003, for the second-longest walk streak in major-league history. He’ll have a chance this weekend to match Roy Cullenbine’s all-time record of 22 consecutive games, set in 1947. Unreal. He saw at least six pitches in four of his five plate appearances on Friday night. The 23-year-old’s ability to control the plate has always been his defining trait, but he’s taken it to another level this season with a staggering 34 walks through 31 games.

Murakami’s blast off Padres starter Germán Márquez gave him sole position of first place league-wide with 13 homers. He’s also in the top 10 in RBI with 26 and walks with 27. In part because of those walks, he currently has an OPS more than four times his batting average (.967 to .239). That’s a feat accomplished just six times by batting-title qualifiers in MLB history: Mark McGwire in 1998 (70 HR) and ’99 (65 HR), Barry Bonds in 2001 (73 HR), Joey Gallo in 2017 and ’21 and Kyle Schwarber in 2023.

The closer madness continues. Helsley had been one of the top performers in the league at the position, posting a 2.53 ERA, 1.31 WHIP and a 15/7 K/BB ratio over his first 10 2/3 innings while converting each of his first seven save chances. No word yet on the severity of the injury or on how long the Orioles expect their closer to be shelved for. Albert Suarez was promoted from Triple-A Norfolk in a corresponding move on Friday.

Tracy noted that the imaging revealed nothing more than inflammation, which is the best possible news that the Red Sox and fantasy managers could hear at this time. He’ll be shut down from throwing for a few days while he builds up strength in his shoulder before he starts to ramp back up. Still no firm timetable on when they expect him to return, but it doesn’t appear to be as dire as originally feared.

Kevin Cash said that Pepiot felt instability in his hip while playing catch on Monday, and it turned out that this was exactly as bad as it sounded. Pepiot finishes the year without throwing a pitch in the major leagues. The 28-year-old will attempt a comeback in 2027. Pepiot was already on the 60-day injured list.

Woof. It’s not a surprise after Woodruff was pulled in the second inning of his last start with a major velocity drop. Brewers manager Pat Murphy said that Woodruff told him he doesn’t feel like he’s injured, but that it was a dead arm situation. We’ll see where this heads, but shoulder injuries for pitchers are not auspicious signs. The optimistic case is that Woodruff is able to shake this off and return in a few weeks with his regular velocity.